By Friedrich Wilhelm Riegels
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The interaction of bcl-2 and Bax proteins determines their ratio and hence, cell survival or death following apoptotic stimulus. 3). 3 MOLECULAR AND CELLULAR EVENTS OF CARCINOGENESIS DURING PROGRESSION A number of oncogenes and tumor suppressor genes are genetically altered in cancer cells, and those alterations accumulate in a stepwise manner during tumor progression (Yokota, 2000). This is evidenced by a greater number of genetic alterations in late-stage than in early-stage tumors. Moreover, the frequencies of alterations in a particular set of genes may be higher in late-stage than in early-stage tumors, whereas the frequencies in another set of genes may be high in both early- and late-stage tumors.